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Melasma Treatment in Dwarka

Melasma is an acquired pigmentary disorder that classically manifests as symmetric hyperpigmented patches on the face. It can sometimes extend to other parts of the body like the neck.
Risk Factors: Certain identifiable risk factors increases the likelihood and severity of melasma development.

  • UV (ultraviolet) radiation

  • Hormonal influences like oral contraceptives and pregnancy

  • Antiseizure medications

  • Thyroid disorders

  • Genetic predisposition

  • Phototoxic medications


Many cases of melasma are still classified as idiopathic in which anyone cause could not be pointed out.
With the recent advances in science and technology, certain newer agents have cropped up which may be useful in targeting the pigmentation of melasma. Below is the list of a few of these ingredients.


Newer And Experimental Agents

  • Aloesin- C glycosylated chromone, derived from aloe vera and has been proven to competitively inhibit the hydroxylation of tyrosinase to DOPA and oxidation of DOPA to dopachrome 

  • Flavanoids- these are benzopyrene derivatives with antiradical activity. They are a competitor for the tyrosinases 

  • Ellagic acid: They are naturally occurring polyphenol and inhibit the proliferation of melanocytes and melanin synthesis by tyrosinase 

  • Gentisic acid- It is derived from Gentian roots. Its alkyl ester is highly effective and less cytotoxic than hydroquinone

  • Hydroxycoumarins- novel antioxidants, which have an alpha-tocopherol like structure

  • Natural derived botanical extracts

  • Rucinol (4-n butyl resorcinol)

  • Soy-active ingredients STI (Soy Trypsin Inhibitor) and Bowman-Birk Inhibitor 

  • Silymarin: It’s a naturally occurring polyphenol flavonoid compound or flavonolignans 

  • Alpha-lipoic acid / thioctic acid / dihydrolipoic acid

  • Dioic acid- agonist to nuclear PPAR, which regulates tyrosinase transcription and melanosome transfer

  • Green tea- green tea phenols (EGCG, epigallocatechin, catechin, gallocatechin gallate, and epicatechin gallate)

  • Octadecenedioic acid (ODA)

  • Orchid extracts

  • 4 hydroxy anisole 

  • Linoleic acid: This molecule accelerates tyrosinase degradation and accelerate the turnover of the stratum corneum.

  • Magnolignan (2,2`-Dihyroxy 5,5` dipropyl biphenyl)

  • Polypodium leucotomos 

  • Cinnamic acid: It is a phenylpropanoid derivative, occurring in plants of cassia and ginseng

  • Pidobenzone /k5 lipogel/ L- proline 5-oxo-4- hydroxyphenyl ester: It is a proline analogue with a benzene ring structure. 

  • TRANEXAMIC ACID -Trans-4 (aminomethyl) cyclohexane carboxylic acid: It is a lysine analogue, known to have antiplasmin activity and hence decreases alpha-MSH, which stimulates melanin synthesis

Oral Agents 

We at Skin Décor use customized treatment plans for each of our patients to help with their melasma. Following are a few of the oral supplements which we can use in our treatment protocols.

  • Oral antioxidants- A combination of oral proanthocyanidin plus vitamin A, C, and E have shown promising results for melasma patients in combination with other treatment protocols.

  • Pycnogenol

  • Oral Glutathione supplements

  • L-cysteine peptide

  • Tranexamic acid- low dose of 250 mg twice a day for at least 3 months

Chemical Peels
Chemical peels used for treating melasma could be superficial level  or medium depth peels. In Indian skin types, extra precaution is needed for doing chemical peels for melasma as the risk of post-inflammatory scarring and pigmentation is there. We at Skin Décor, customize peels according to our patients. Following are the selections of peels that can be used in Melasma.

  • Alpha and beta-hydroxy peels – Glycolic acid, Salicylic acid, Jessner’s solution, TCA peel, Azelaic acid peels

  • Lactic acid peels- 92%

  • Pyruvic acid- concentration of 40% - 70% as a superficial peeling agent

  • Tretinoin peels

  • Acidified amino acid peels

  • Mandelic acid

  • Lipohydroxy acid


Lasers

  • ​Resistant melasma cases are particular candidates for laser therapy. The quality of the laser machine with its appropriate patient selection is a must to achieve maximum results decreasing the side effect profile. 

  • Fractional Photothermolysis (1535,1550 nm)using our signature laser treatment protocol could be really beneficial in selected patients.

  • Fractional CO2 and Q switch Nd Yag laser- They have good results. However, maintenance is the key with laser treatment sessions for melasma as recurrences can occur.