Melasma is an acquired pigmentary disorder that classically manifests as symmetric hyperpigmented patches on the face. It can sometimes extend to other parts of the body like the neck.
Risk Factors: Certain identifiable risk factors increases the likelihood and severity of melasma development.
Many cases of melasma are still classified as idiopathic in which anyone cause could not be pointed out.
With the recent advances in science and technology, certain newer agents have cropped up which may be useful in targeting the pigmentation of melasma. Below is the list of a few of these ingredients.
Aloesin- C glycosylated chromone, derived from aloe vera and has been proven to competitively inhibit the hydroxylation of tyrosinase to DOPA and oxidation of DOPA to dopachrome
Flavanoids- these are benzopyrene derivatives with antiradical activity. They are a competitor for the tyrosinases
Ellagic acid: They are naturally occurring polyphenol and inhibit the proliferation of melanocytes and melanin synthesis by tyrosinase
Gentisic acid- It is derived from Gentian roots. Its alkyl ester is highly effective and less cytotoxic than hydroquinone
Hydroxycoumarins- novel antioxidants, which have an alpha-tocopherol like structure
Natural derived botanical extracts
Rucinol (4-n butyl resorcinol)
Soy-active ingredients STI (Soy Trypsin Inhibitor) and Bowman-Birk Inhibitor
Silymarin: It’s a naturally occurring polyphenol flavonoid compound or flavonolignans
Alpha-lipoic acid / thioctic acid / dihydrolipoic acid
Dioic acid- agonist to nuclear PPAR, which regulates tyrosinase transcription and melanosome transfer
Green tea- green tea phenols (EGCG, epigallocatechin, catechin, gallocatechin gallate, and epicatechin gallate)
Octadecenedioic acid (ODA)
4 hydroxy anisole
Linoleic acid: This molecule accelerates tyrosinase degradation and accelerate the turnover of the stratum corneum.
Magnolignan (2,2`-Dihyroxy 5,5` dipropyl biphenyl)
Cinnamic acid: It is a phenylpropanoid derivative, occurring in plants of cassia and ginseng
Pidobenzone /k5 lipogel/ L- proline 5-oxo-4- hydroxyphenyl ester: It is a proline analogue with a benzene ring structure.
TRANEXAMIC ACID -Trans-4 (aminomethyl) cyclohexane carboxylic acid: It is a lysine analogue, known to have antiplasmin activity and hence decreases alpha-MSH, which stimulates melanin synthesis
We at Skin Décor use customized treatment plans for each of our patients to help with their melasma. Following are a few of the oral supplements which we can use in our treatment protocols.
Chemical peels used for treating melasma could be superficial level or medium depth peels. In Indian skin types, extra precaution is needed for doing chemical peels for melasma as the risk of post-inflammatory scarring and pigmentation is there. We at Skin Décor, customize peels according to our patients. Following are the selections of peels that can be used in Melasma.
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